EVIDENCE OF ZIKA VIRUS CIRCULATION IN HUMAN AND LIVESTOCK IN CHAD

Evidence of Zika virus circulation in human and livestock in Chad

Zika virus (ZIKV) is a major blade guard public health problem worldwide.After several reported outbreaks, the current extent of infections caused by this orthoflavivirus in the Sahel remains to be explored.We investigated the prevalence of neutralizing antibodies against ZIKV in the general population, in HIV-infected individuals and in livestock

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Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor

Summary: AAA+ proteins form asymmetric hexameric rings that hydrolyze ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops.Understanding how ATPase and threading activities are regulated and intertwined is key to understanding the AAA+ protein mechanism.We studied the disaggregase ClpB, which contains

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